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pentobarbital decreases amounts of ponatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Stay clear of Except the coadministration outweighs the attainable risk of ponatinib underexposure; keep track of for signs of lowered efficacy.pentobarbital raises effects of ifosfamide by influencing hepat